European multicenter harmonization study shows anaplastic lymphoma kinase immunohistochemistry testing comparable to, if not better than, fluorescence in situ hybridization testing

Sixteen institutions across Europe collaborated together to show for the first time that a semi-quantitative anaplastic lymphoma kinase protein expression test, immunohistochemistry, is reliable amongst several laboratories and reviewers when test methodology and result interpretation are strictly standardized and the scoring pathologists are appropriately trained on the test. —> Read More Here

Scientists Say Proof Of Jack The Ripper’s Identity Is Fatally Flawed

Who was Jack the Ripper?

Last month the author of a new book entitled Naming Jack The Ripper said he had irrefutable evidence that the notorious serial killer who terrorized London in the late 1880s was a Polish émigré named Aaron Kosminski.

The author, Russell Edwards, went so far as to say that “only non-believers that want to perpetuate the myth will doubt his contention.”

Doubt, however, is exactly what’s surrounding Edwards’ claim, which has been called into question by a scathing follow-up report published this week by The Independent.

Edwards had enlisted the help of forensics expert Dr. Jari Louhelainen, a senior lecturer in molecular biology at Liverpool John Moores University, to analyze a bloodstained shawl that purportedly had been retrieved from the murder scene of Catherine Eddowes, one of Jack the Ripper’s victims.

Louhelainen reportedly extracted fragments of mitochondrial DNA from the fabric, later matching these with DNA taken from living descendants of both Eddowes and Kosminski. But The Independent says Louhelainen may have erred in the way he matched the DNA samples.

Louhelainen said the DNA from the shawl and from one of Eddowes’ descendants contained 314.1C, a mutation that is —> Read More Here

One-Of-A-Kind Fossil Reveals Stegosaur’s Deadly Side

stegosaurs tails

A one-of-a-kind fossil shows that stegosaurs weren’t quite the gentle giants some assume them to have been.

The fossil — of the pubic bone of another Late Jurassic dinosaur known as Allosaurus — shows clear evidence of a brutal attack by a stegosaur, according to the scientists who have been studying it.

Unearthed in Wyoming in 1999, the fossil seems to confirm the theory among paleontologists that stegosaurs used their spiked tails in combat with other animals.

“This is the only specimen we have where you can see the entry wound for a stegosaur assailant,” Dr. Robert Bakker, a paleontologist at the Houston Museum of Natural Science and one of the scientists who discovered the wound, told The Huffington Post. “When animals get chewed up or beat up, you ever hardly have clear evidence… and we have one for this.”

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The tail spike of a stegosaur seems to have entered the allosaur’s pubis from below and passed all the way through. The researchers believe the wound resulted in a lethal infection.

Why are the scientists so sure it was a stegosaur that delivered the wound? Because, they say, the size and shape of the wound match up —> Read More Here

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