Gastric Reflux Drugs May Be Tied To Dementia Risk

Reuters Health – Repeated use of a certain class of drugs for gastric reflux or peptic ulcers was linked with a higher risk for dementia among patients in Germany, researchers say.

The drugs, known as proton pump inhibitors (PPIs), include lansoprazole (Prevacid), esomeprazole (Nexium), and omeprazole (Prilosec), all manufactured by AstraZeneca.

The current study can only provide a statistical association between PPI prescriptions and occurrence of dementia in the elderly. It can’t prove that PPIs actually cause dementia, said senior author Britta Haenisch of the German Center for Neurodegenerative Diseases in Bonn, Germany.

“In our analysis we focused on long-term regular PPI prescription for at least 18 months,” Haenisch told Reuters Health by email.

The researchers examined medical records from 2004 through 2011 from more than 73,000 patients age 75 and older, mostly women.

They classified 2,950 of those patients as regular PPI users, meaning they had at least one prescription for one of the drugs every four or five months over an 18-month period.

During the study period, 29,510 people developed dementia.

Regular PPI users were 44 percent more likely to develop dementia than those who were not receiving the drugs, the authors reported in JAMA Neurology.

The researchers couldn’t know whether some of the people in the study were at increased risk for dementia to start with, Haenisch said.

PPI use and dementia may both be influenced by similar risk factors, Dr. Lewis H. Kuller of the University of Pittsburgh wrote in an editorial accompanying the results.

In the Women’s Health Initiative, for example, women who took PPIs were more often obese, had arthritis, and had poorer health generally than others, which may increase dementia risk, Kuller wrote.

The drugs do carry an increased risk of kidney disease, fracture, low magnesium levels, gastrointestinal infections, Clostridium difficile infection and pneumonia, Kuller told Reuters Health by email.

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