Key without a lock: Only the balance between receptors controls blood vessel development

Tie1 is a receptor on the surface of blood vessel wall cells whose binding partner has not yet been found. Mice whose cells have no Tie1 are not viable. Scientists have now been able to elucidate the complicated molecular mechanism by which Tie1 controls the function of a related receptor called Tie2. Thus, Tie1 regulates essential functions of blood vessels without binding to a growth factor. —> Read More