Multiple pathways progressing to Alzheimer’s disease

The amyloid cascade hypothesis of Alzheimer’s disease (AD) posits that sticky aggregations or plaques of amyloid-beta peptides accumulate over time in the brain, triggering a series of events that ultimately result in the full-blown neurodegenerative disorder. The hypothesis has been a major driver of AD research for more than 20 years. However, in a new study, researchers suggest the picture is not so clear-cut, reporting that early indicators or biomarkers of AD development are not fixed in a specific sequence. —> Read More